Physical Activity And Activity Energy Expenditure Are Inversely Correlated With Serum Metabolites Of The Metabolic Syndrome, Body Mass Index And Central Obesity

Ilona CSIZMADI, Alberta Health Services, Canada
PALMNAS M. 1,2 , SHAYKHUTDINOV R. 2 , ROBSON P. 3 , MIGNAULT D. 4,5 , RABASA-LHORET R. 4,5 , VOGEL H. 1,2

1 Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
2 Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
3 C-MORE, CancerControl Alberta, Alberta Health Services,Calgary, Alberta, Canada
4 Institut de recherches cliniques de Montréal, Montréal, Quebec, Canada
5 Département de nutrition, Université de Montréal, Montréal, Quebec, Canada
6 Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada
7 Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

Modifiable lifestyle factors, including physical activity and activity energy expenditure (AEE), may attenuate unfavorable health effects of obesity, including components of the metabolic syndrome (MetS) and chronic diseases such as cancer, although the underlying mechanisms are not clear. In this study we sought to investigate whether the metabolic profiles of MetS and adiposity assessed by BMI and central obesity are inversely correlated with physical activity and AEE. We studied 47 women and 35 men, aged 30-60 years, using doubly labeled water to derive AEE and physical activity level and the Sedentary Time and Activity Reporting Questionnaire (STAR-Q) to determine time spent in moderate and vigorous physical activity. Proton nuclear magnetic resonance spectroscopy was used for serum metabolomics analysis. Serine and glycine were found in lower concentrations in participants with more MetS components and greater adiposity. In contrast, serine and glycine concentrations were higher with higher levels of physical activity and AEE in those with and without MetS components. Pathway analysis suggested that the lower serine and glycine concentrations could be a consequence of serine entering sphingolipid metabolism. In conclusion, this exploratory study suggests that the metabolic profiles of MetS and adiposity, and serine and glycine in particular, may be inversely associated with physical activity and AEE. It also provides a potential mechanistic link between obesity and obesity-related diseases. Although promising, future studies need to assess the results relevance to the prevention of obesity-related diseases including cancer.