Tobacco, Alcohol And Head And Neck Cancer In Three Brazilian Regions

Suely KFOURI, School of Public Health , University of São Paulo- Brazil, Brazil
ELUF-NETO J. 2 , KOIFMAN S. 3 , CURADO M. 4 , MENEZES A. 5 , ALEXANDER D. 6 , WUNSCH FILHO V. 7

1 Department of Epidemiology, University of São Paulo, Brazil
2 Department of Preventive Medicine, University of São Paulo, Brazil
3 Osvaldo Cruz Foundation, Rio de Janeiro, Brazil
4 Registration Coordinator of the Population Based Cancer Goiânia, Goiás, Brazil.
5 Faculty of Medicine, Federal University of Pelotas, Brazil,
6 Hospital de Clinicas de Porto Alegre, RS, Brazil
7 Department of Epidemiology, University of São Paulo, Brazil

Objective. In this case-control study, we compared the probabilistic reasons of risk of smoking and alcohol consumption in the Head and Neck Cancer (HNC) in three Brazilian regions: Midwest, Southeast and South. Method. The study included 1.594 cases of HNC and 1.292 hospital controls. Odds ratio and respective intervals with 95% confidence were estimated by unconditional logistic regression with adjustment for age, sex, education, consumption of fruit and vegetables, smoking (for exam of alcohol effect) and alcohol consumption (for exam of smoking effect). It was also calculated the attributable proportion risk (APR) of tobacco and alcohol in the HNC. Results. The effect of smoking in HNC was more significant in the population of the Midwest compared to those of the Southwest and South. On the other hand, the alcohol abuse induced major risk of HNC in the population of Southwest and Midwest of Brazil. Conclusion. These results suggests distinct profiles of culture and customs in the populations that influence the patterns of consumption of tobacco and alcohol.