BMI Changes In The Follow-Up And The Risk Of Lung Cancer: A Prospective Study In China Kailuan Male Cohort

Shuanghua XIE, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China
WANG G. 2 , CHEN S. 3 , WU S. 3 , FENG X. 1 , LV Z. 1 , DAI M. 1 , LI N. 1

1 National Office for Cancer Prevention and Control, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
2 Department of Oncology, Kailuan General Hospital, Tangshan,China
3 Department of Cancer Prevention and Control, Kailuan General Hospital, Tangshan,China

​Purpose: To investigate the association between BMI changes in the follow-up and male lung cancer incidence. Methods: A population-based cohort study was conducted in the whole male population, Kailuan Group, China during 2006 to 2011. By December 31, 2011, we followed 75151 men aged 18-108 years old. Cancer incidence information was obtained through follow-up and examination every two years and the records interview from the Financial Department of Kailuan Group, who was responsible for health reimbursement and death benefit of the group population. Incident cases occurred within 1 year after baseline interview was excluded. Body height and weight were measured by trained medical assistants. BMI changes in the follow-up were measured as the average annual proportional changes of BMI between the last follow-up and baseline interview, and were categorized into 5 groups: stable group (reference), minor loss or gain, and major loss and gain. Results Baseline BMI was inversely associated with lung cancer (highest tertile vs. lowest: HR=0.64, 95% CI: 0.44-0.94). While, the major loss and gain of BMI increased the risk of lung cancer (major loss vs. stable: HR=4.04, 95%CI: 2.15-7.59; major gain vs. the stable: HR=3.75, 95%CI: 1.99-7.07). Conclusions Major BMI changes in short term, both loss and gain, might indicate a potential role for body weight-related biological pathway in the development of male lung cancer.
Funding source: National Natural Science Fund of China (grant no. 81172757 )