Circulating Inflammatory Markers And Risk Of Differentiated Thyroid Carcinoma In EPIC

Laure DOSSUS, International Agency for Research on Cancer, France
TRAVIS R. 1 , WEIDERPASS E. 2,3,4 , SCALBERT A. 6 , ROMIEU I. 6 , FRANCESCHI S. 5 , RINALDI S. 6

1 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
2 Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway
3 Department of Community Medicine, Faculty of Health Sciences, University of Tromsų, The Arctic University of Norway, Tromsų, Norway
4 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
5 Infections Section, IARC, Lyon, France
6 Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France

Purpose
This work is part of the ongoing project to study the aetiology of differentiated thyroid carcinomas (TC) within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort and establish the fraction of possible overdiagnosis in different countries using cancer registry data. Previous results showed direct associations of TC risk with obesity, total energy intake, low consumption of polyunsaturated fatty acids, low alcohol intake. For biomarkers, we found positive associations with circulating concentrations of thyroglobulin and insulin-like growth factor and a negative association with thyroid stimulating hormone. In women, little associations were observed with reproductive history and female hormone use. To further understand the association between overweight and obesity (a state of chronic inflammation) with TC risk, we have set up a study to investigate the relationship between the risk of differentiated TC in men and women and the concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IFN-γ, IL-10 and TNF-α.
Methods
A case-control study has been nested within EPIC. Among subjects with a blood sample, 483 first primary incident differentiated TC cases have been identified (404 women and 79 men) and matched on pertinent variables to two (women), or three (men) controls chosen among cancer-free cohort participants by incidence density sampling. Biomarkers are currently being measured on serum samples using previously validated, highly sensitive commercially available immunoassays. Relative risk of differentiated TC by levels of each biomarker will be estimated using conditional logistic regression.
Results
Analyses are ongoing and will be completed in May. Preliminary results will be presented at the meeting.
Conclusions
The proposed study is the first prospective study conducted on inflammation, cytokines and differentiated TC risk, and will provide insights on mechanisms relating overweight and obesity to TC risk. It may inform strategies for the prevention and control of the disease.
Funding: Institut National du Cancer