Factors associated with survival in individuals diagnosed with head and neck cancer in a public institution of reference in Rio de Janeiro, Brazil

Luis Felipe RIBEIRO PINTO, Brazilian National Cancer Institute , Brazil
BERGMANN A. 2 , COSTA I. 3 , DIAS F. 4 , PINTO L. 5

1 Molecular Carcinogenesis Program, National Cancer Institute, Rio de Janeiro, Brasil
2 Molecular Carcinogenesis Program, National Cancer Institute, Rio de Janeiro, Brasil
3 Head and Neck Surgery Section, National Cancer Institute, Rio de Janeiro, Brasil
4 Head and Neck Surgery Section, National Cancer Institute, Rio de Janeiro, Brasil
5 Postgraduate Oncology Program, National Cancer Institute, Rio de Janeiro, Brasil

Objective: To analyze the factors associated with survival in individuals diagnosed with head and neck cancer. Methods: Cohort study in a public institution of reference in Rio de Janeiro. We excluded individuals with cancer in the nasopharynx, glands and thyroid; those diagnosed for more than 6 months and those who didn’t contribute to the follow-up. 504 individuals were eligible. A descriptive analysis was conducted. Survival analysis using the Kaplan-Meier method was performed. To identify differences between the categories we used the log-rank test. In univariate analysis, the variables with p<0.20 were selected. The Cox regression by forward stepwise method was performed to estimate the risk to different factors. The variables with p<0.05 were retained in the final model. This study is part of a larger project called "Head and Neck Cancer Study in Brazil". Results: The mean age of the population was 61 years (SD = 10.48). Most are male, white, low education, overweight or obese, have a reasonable/poor oral health, smokers or former smokers and currently drink or had in the past, and uses both types of beverages. Most consumes few vegetables and fruit, but included in their daily meals rice and bean. The mate consumption was very low (0.8%). Overall survival at 2 years was higher for larynx cancer (p=0.347). There were 171 deaths (33.9%). Survival was higher in younger individuals (59.6%), female (71.8%,), white (62.0%), overweight or obese (68.6%), higher education (66.8%), with daily intake of vegetables (66.6%), fruit (60.2%), bean (59.1%) and rice (59 6%). For those with good oral hygiene survival was greater (75%). After multiple analyzes, BMI (HR = 1.59; p = 0.007) and oral hygiene (HR = 1.89; p = 0.013) were retained in the model. Conclusion: The survival rate in this population is associated with BMI and oral hygiene.