Update On Progress With An Update To The British Rubber Industry Study Cohort And With An International Pooled Study Of Rubber Industry Cohorts

Damien MCELVENNY, Institute of Occupational Medicine, United Kingdom
MACCALMAN L. 1 , HIDAJAT M. 2 , ALEXANDER C. 1 , CHERRIE J. 1,3 , DARNTON A. 4 , AGIUS R. 5 , STRAIF K. 6 , DE VOCHT F. 2

1 Research Division, Institute of Occupational Medicine, Edinburgh, UK
2 School of Social and Community Medicine, University of Bristol, Bristol, UK
3 School of Life Sciences, Heriot Watt University, Edinburgh, UK
4 Statistics and Epidemiology Unit, Health and Safety Executive, Bootle, UK
5 Institute of Population Health, University of Manchester, Manchester, UK
6 Section of IARC Monographs, International Agency for Research on Cancer, Lyon, France

Here we present progress on an update of a British cohort of rubber industry workers and for an international pooled cohort study coordinated by the International Agency for Research on Cancer.
The UK cohort consists of 40,867 men aged 35+ who were employed in the British rubber industry on 1 February 1967.  The previous analysis found an excess of bladder cancer mortality where exposure to antioxidants may have occurred.  An excess of lung cancer was observed in the total industry.  We have received research governance clearances from ethics, Health Research Authority Confidentiality Advisory Group, Office for National Statistics’ Microdata Release Panel, the Health and Social Care Information Centre (HSCIC) Data Access Advisory Group for England and Wales and Public Benefit and Privacy Panel for Scotland for mortality and cancer incidence follow-up.  The cohort is currently being traced for mortality by HSCIC and we plan to present preliminary results at the meeting in June.
Preliminary results will be presented on trend analyses for UK-exposure information from the EXASRUB database, which will develop exposure models specifically for the British industry.  Sensitivity analyses to investigate the assumptions made as part of the exposure assessment will also be carried out.
The international pooled study anticipates pooling data from Great Britain, Poland, Germany, Holland and Sweden, making this not only the largest ever evaluation of cancer risks in the rubber industry, but also the first large investigation using quantitative exposure assessments for a number of potential carcinogens pertinent to this industry.  We will report on progress with the international pooled study.